Catalog Number - 68322-15P

68322-15P Cogent RP PFP™ HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering reliable performance and enhanced selectivity for complex separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using ultra‑high purity silica.

The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it especially effective for halogenated, aromatic, and polar analytes. It also serves as a suitable alternate column for USP methods where PFP selectivity is beneficial.

With a 3 µm particle size, this column offers higher efficiency than 5 µm columns of the same phase, resulting in sharper peaks and improved resolution. As expected, the smaller particle size generates increased backpressure compared to larger particle columns.

150 mm Length – Maximum Resolution for Analytical Separations

The 150 mm length delivers maximum resolving power, making it ideal for complex mixtures and difficult separations.

• Higher resolution compared to shorter column lengths

• Improved separation of closely related compounds

• Increased peak capacity for complex samples

✅ Recommended for analytical methods requiring the highest resolution

Flow Rate & System Requirements (4.6 mm ID, 3 µm)

⚠️ Compatible with standard analytical HPLC systems, with moderate to higher backpressure

• Typical flow rate range: ~0.8 – 1.5 mL/min

• Higher efficiency than 5 µm columns

• Increased backpressure due to smaller particle size

• Suitable for UV and standard analytical detectors

✅ Best Practice: Filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP (F5) Columns for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with halogenated and fluorinated analytes

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for method development

Versatile 100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Balanced performance across applications

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry

High Efficiency (3 µm Particles)

• More efficient than 5 µm columns

• Sharper peaks and improved resolution

High Purity Silica

• Consistent and reproducible chromatographic performance

• Long column lifetime

Typical Applications

• Halogenated compound analysis

• Aromatic compound separations

• Polar analyte retention

• Pharmaceutical QA/QC workflows

• Method development and optimization

• USP alternate methods

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Higher backpressure compared to larger particle sizes

• Use 0.2 µm filtration prior to injection